Drugs that protect the stomach lining do not harm the stomach
The first thing to be explained is that the drugs that protect the gastric mucosa will certainly not hurt the stomach, and the time of taking such drugs is mainly related to the mechanism of drug effect.
Under normal circumstances, the surface of the gastric mucosa has a natural protective layer, which is composed of mucus and alkaline substances secreted by the gastric mucosa itself. This allows stomach acid and pepsin to digest food without harming the stomach lining.
Helicobacter pylori, drugs, alcohol and many other factors will lead to the gastric mucosa secreting mucus function is weakened, and then lead to gastric acid and pepsin break through the protective layer, damage the gastric mucosa, inflammation, erosion and even ulcers.
In order to promote the repair of gastric mucosa and protective layer, medical experts have developed a variety of gastric mucosa protective drugs. At present, gastric mucosal protection drugs are adjuvant drugs for gastritis, gastric and duodenal ulcer and other diseases.
Works differently
Before or after dinner, make no mistake
According to different mechanisms of action, gastric mucosal protective drugs are generally divided into two categories:
A class of drugs, the effect requires the participation of stomach acid, such as sulcoaluminum, bismuth potassium citrate, etc. (containing aluminum, bismuth metal ions), should be taken before meals on an empty stomach, drug powder or particles and stomach acid and gastric juice mixed to form a drug protective layer over the original natural protective layer, this effective process can be compared to the effect of flour and water to form a flatbread.
Gastric mucosa under the protective layer of drugs, to avoid gastric acid, pepsin and food stimulation, is conducive to self-repair. Taking medicine after meals will lead to the drug and food mixed together, can not form a good protective layer, is not conducive to the play of the drug effect.
Another class of drugs, the effect does not require the participation of stomach acid, such as gefaraxate, Tepredone, Rebabat, etc., the drug is absorbed in the digestive tract and transferred to the gastric mucosa, which promotes the recovery of the natural protective layer by enhancing the self-repair ability of the gastric mucosa.
Taking drugs before or after meals will have different effects on the absorption of this class of drugs: Gefaraxate and tipredone are better absorbed after meals, so it is recommended that they be taken half an hour after meals; Absorption of Rebabapide is delayed when taken after meals, so it is recommended to take it early in the morning, before dinner, and before bed. This type of medication usually needs to be taken three times a day in order for it to continue to work.
Contains aluminum and bismuth
Attention should be paid to the use of these gastric mucosal protective drugs
At present, the main treatment for gastric diseases such as gastric ulcer and gastritis is to inhibit the secretion of gastric acid, so as to reduce the stimulation of gastric acid on gastric mucosa and create conditions for its repair. However, inhibition of gastric acid secretion will affect the effectiveness of drugs such as sulfoaluminum and bismuth potassium citrate, so the clinical application of these gastric mucosal protective drugs dependent on gastric acid has a decreasing trend.
However, their respective pharmaceutical properties make them useful for treating specific diseases. Sulfoaluminum can enhance the gastric mucosal barrier and bind bile acid in bile, thereby reducing or eliminating the gastric mucosal damage caused by bile reflux. Bismuth potassium bismuth citrate and other bismuth agents have anti-helicobacter pylori effect, combined with acid suppressors and antibacterial drugs to eradicate helicobacter pylori.
It is worth mentioning that gastric mucosal protection drugs containing aluminum and bismuth should pay attention to several points during use:
(1) Drugs containing aluminum and bismuth should not be taken for a long time, usually not more than 8 weeks;
(2) Aluminum and bismuth ions will be absorbed into the body in a small amount, which may cause accumulated poisoning when kidney function is damaged, so patients with renal insufficiency should consult a doctor or pharmacist before taking the drug;
(3) Aluminum and bismuth ions may combine with other drugs, affecting the absorption of other drugs (such as tetracycline), and should be at least 2 hours apart from other drugs when combined;
(4) Drugs containing aluminum can cause constipation, and patients with habitual constipation should not use them; The drug containing bismuth will make the stool turn dark brown, which is a normal phenomenon and can disappear after 2-3 days of stopping the drug.
