1.Nucleic acid testing. The network laboratory carried out multi-pathogen nucleic acid detection, including Bordetella pertussis, on samples submitted by sentinel hospitals undertaking multi-pathogen surveillance of acute respiratory infectious diseases.
The data of multi-pathogen detection results will be input into the corresponding module of the "China Influenza Surveillance Information System" before 24:00 every Monday.
2.Etiological identification. The network laboratory will carry out pathogen isolation, culture and serotype analysis on the samples tested positive for pertussis Bordetella nucleic acid, and report the results of the previous month in the "National Pathogen Identification Network" information system before the 5th day of each month.
3.Gene sequencing. Target gene or whole gene sequencing of positive culture of Bordetella pertussis was carried out in network laboratory. In principle, no less than 10 copies/province per year,
if less than 10 copies are detected in the whole year, all will be sequenced. The network laboratory should report the sequencing results of the previous month on the information system of the National Pathogen Identification Network before the 5th of each month.
(3) Special investigation. Regions where conditions permit are encouraged to organize special investigations in epidemiology, etiology and serology to grasp the epidemic trend, disease burden and etiological changes of pertussis, and provide support for scientific and accurate prevention and control work. The China CDC has strengthened guidance and technical support for key regions.
School-age children should be vaccinated with acellular DTaP vaccine (DTaP) as early as possible and throughout the whole process in accordance with the childhood immunization procedures of the National Immunization Program.
If other vaccines containing pertussis components have been administered according to the vaccination instructions, they may be considered to have completed the corresponding dose of vaccination.
If acellular DTaP vaccination has not been completed at the recommended age, it should be replaced as soon as possible, only with the remaining dose, and there is no need to restart the full course of vaccination.
People who have contact with pertussis cases (from 1 week before the onset of disease to 3 weeks after the onset of disease) in common living, living, studying or working should undergo self-health monitoring for 21 days.
During this period, they can study and work normally if there is no discomfort such as cough, runny nose or fever. Avoid close contact with key groups such as infants and pregnant women, and reduce visits to crowded places. Once cough, runny nose, fever and other symptoms, should be seen in time.
For infants and young children who have not been fully vaccinated with pertussis vaccine, close contacts in the family and in childcare facilities, staff in childcare facilities with a clear history of exposure,
infant caregivers, medical workers in neonatal units, etc., it is recommended to receive drug prophylaxis within 21 days after exposure (if possible within 1-2 weeks after exposure) under the guidance of a clinician.
(1) Definition of cluster outbreaks. Refers to the reporting of 3 or more clinically diagnosed or laboratory-confirmed cases of pertussis within 7 days in key institutions with populations aged 6 and below gathered in the same nursery institution,
maternity center, child welfare institution and minor assistance and protection institution; 10 or more clinically diagnosed or laboratory-confirmed cases of pertussis were reported within 7 days in the same school or other collective unit.
(2) Reports of cluster outbreaks. When pertussis clusters are found, county-level disease control agencies should report them through the public health Emergency Management information System within 2 hours,
and the event level should be selected as "unclassified". In accordance with the grading standards for public health emergencies in the National Emergency Plan for Public Health Emergencies, the event levels of pertussis epidemics should be further determined and corrected in a timely manner.(3) Identification and management of close contacts.
1.Definition of close contacts. Refers to a person who has close contact with pertussis cases from 1 week before the onset of the disease to 3 weeks after the onset of the disease, such as living, studying,
working, living, etc. For cases treated with effective antibiotics, the determination period of close contacts is from 1 week before the onset of the case to 5 days after effective antibiotic treatment.
2.Identification of close contacts. Based on the results of epidemiological investigation and exposure risk assessment of cluster outbreaks, county-level CDC agencies are responsible for determining close contacts in a timely manner.
3.Close contact management. County-level disease control agencies or medical institutions guide close contacts to do self-health monitoring, and the health monitoring period is 21 days from the date of the last close contact with the case.
