Will Smith was accepted into a "prep (summer) program" for high school students at the Massachusetts Institute of Technology, but he chose not to attend, opting instead for a rap career.

In 2003, he was executive producer of the crime action film The Ultimate Murder, starring Duane Martin, Vivica Fox and Megan Goode. In April, he won the 16th American Kids' Choice Awards Wannabe Award. In July, the action film "Jedi Men 2" with Martin Lawrence was released, playing Mike Lowry, a playful, unscrupulous and often troublesome Miami narcotics detective; In the same year, he was the creator and executive producer of the family sitcom All of Us.

In 2004, he was executive producer of the romantic comedy The Empty Seat, starring Shemar Moore and Melanie Brown. In July, he starred in and produced the sci-fi action film "Public Enemy of Machines," in which he played Dale Spooner, a police detective who is suspicious of robots; In October, the comedy 3D animated film "Shark Story" was released, Will Smith voiced the fast-talking fish Oscar, and he won the favorite animated voice award at the 18th American Kids' Choice Awards. In the same year, he was the producer of the love film Face, starring Yang Yahui and Chen Chong.

In January 2005, he won the 31st People's Choice Award for Favorite Action Movie Actor. On February 11, with Eva Mendes, Kevin James co-starring in the romantic comedy "National Rival" released, playing the humorous marriage counselor Alex Hitch, he won the 19th American Children's Choice Award for favorite movie actor; In the same month, he won the honorary Cesar Award of the 30th French Film Awards; In March, he released his solo studio album "Lost and Found" through Universal Records. In November, he won the Favorite Pop Rock Male Artist Award at the 33rd American Music Awards.

In 2006, he was the producer of the sports comedy New American Story, starring T.I. and Lauren London. Starring alongside Jaden Smith in the biographical film The Pursuit of Happyness, as black American investment expert Chris Gardner, the film box office exceeded $300 million, Will Smith won the 9th Teen Choice Award for Best Drama Actor Award, Best Chemistry Award (with Jaden Smith), He was nominated for the Best Actor Award at the 79th Academy Awards and the Best Actor Award at the 64th Golden Globe Awards.

In 2007, he co-starred with Alice Braga and Sally Richardson in the apocalyptic sci-fi film I Am Legend, playing Robert Neffer, the only human in Manhattan not infected by the virus, which made more than $570 million at the global box office. He won Best Actor at the 17th MTV Movie Awards, Best Actor at the 34th Saturn Awards, and Best Actor in a Horror Thriller at the 10th Teen Choice Awards. In December, he received a star on the Hollywood Walk of Fame.

In 2008, he was the producer of the adventure drama The Secret Life of Bees. In July, with Charlize Theron and Jason Bateman, the action comedy film "Universal Superman Hancock" was released, and Will Smith played the superman John Hancock who did not play according to the cards, and he won the favorite movie actor award at the 22nd American Kids' Choice Awards. In December, the inspirational film "Seven Pounds" starring Will Smith as Tim, an Internal Revenue Service employee who becomes depressed due to the death of his wife, was released. He won the best Actor award at the 40th National Association of Colored People Awards for the film; In the same year, he was the producer of the drama film The Human Contract. In addition, he co-produced the thriller film Legal Invasion with James Rust.

In January 2009, he won Favorite Movie Actor and Favorite Action Movie Actor at the 35th People's Choice Awards. In May, he was awarded the Humanitarian Award at the Simon Wiesenthal Center; In June, he won the Best Actor Award at the 9th Black Entertainment Television Awards. In 2010, he was the producer of the action film The Karate Kid, starring Jackie Chan and Jaden Smith. In 2011, he announced the production of his fifth studio album.

In 2012, he was the producer of the romantic comedy film "The Dead Man," starring Reese Witherspoon, Chris Pine and Tom Hardy. In May, the sci-fi film Men in Black 3, co-starring Tommy Lee Jones and Josh Brolin, was released.

In 2013, she guest-starred in the comedy film Anchorman 2: The Legend Continues. That same year, the science fiction film After Earth, co-starring Jaden Smith, was released, starring Will Smith as the legendary general Seife Ricci.

In 2014, she guest-starred in the romance film "The Winter Adventure" starring Colin Farrell and Russell Crowe. In the same year, he was the producer of the musical comedy Annie: New York, starring Quvenzhane Wallis and Jamie Foxx.

In February 2015, the comedy crime film Focus, co-starring Margot Robbie and Adrian Martinez, was released, starring Will Smith as Nicky, a middle-aged man who works in fraud. In December, he co-starred with Gugu Mbata-Raw and David Moss in the biopic The Shock Effect, in which he played Dr. Bennet Omalu, a neuropathologist, for which he won the 19th Hollywood Film Award for Best Actor and the African American Film Critics Association Award for Best Actor.

In 2016, he co-starred with Margot Robbie, Joel Kinnaman and others in the sci-fi action-adventure film "Suicide Squad", playing Floyd Laughton, who is proficient in all kinds of firearms. In April, she won the MTV Generation Award at the 25th MTV Movie Awards. In December, the drama Subsidiary Beauty, starring Keira Knightley, Helen Mirren and others, was released, starring Will Smith as Howard, a depressed advertising agency manager who experiences life changes.

In December 2017, the sci-fi film Light Spirit, starring Joel Edgerton and Noomi Rapace, was released, in which he played Scott Ward, a human police officer who was suspicious of his orc partner.

In May 2018, the theme song "Live It Up" was released for the 2018 FIFA World Cup in Russia, featuring Will Smith, Nikki Jaime, and Ella Istraffi, and was produced by DePaulo. In the same year, he narrated the National Geographic Channel 10-part documentary A Strange Stone.

On May 24, 2019, the fantasy adventure film "Aladdin" co-starring Mona Masood and Naomi Scott was released, in which Smith played a humorous genie who can grant the owner's three wishes, and he won the 21st Best Actor in a science fiction/Fantasy film; In August, he was ranked 10th on Forbes' list of the world's highest-paid male actors with earnings of $35 million. In October, the sci-fi thriller "Gemini Killers," starring Mary Elizabeth Winstead and directed by Ang Lee, was released; In December, the animated action adventure film The Change of Agent was released with the voice of Tom Holland, as the voice of elite agent Lance.

In January 2020, the action film Jedi Men: Hot Pursuit, starring Martin Lawrence, was released.

On November 19, 2021, the biopic King Richard will be released, in which he plays Richard Williams, who relentlessly pushes his daughter to the Grand Slam of tennis.

On March 27, 2022, he won the best actor for the film "King Richard" at the 94th Academy Awards. That night, Will Smith slapped his wife for joking with Chris Rock, which caused a series of controversies. On April 1, Will Smith said he had resigned from the Academy of Motion Picture Arts and Sciences; On April 8, the Academy of Motion Picture Arts and Sciences announced that Will Smith has been banned from any of its events or programs for the next 10 years because of the assault. On December 2, he starred in the action thriller film Emancipation, which was released in North America, in which he played Peter, a black man who escaped from the bondage of slave owners in the American South after suffering torture.

In March 2023, Jedi Men 4 has entered the actual preparatory stage. Will Smith is returning to the cast.