Xiang Qian, tenured professor and clinical director of pain and neurosurgery at Stanford University, said: "This line of thought is also extremely unique and innovative on an international scale.
I am very much looking forward to the community gathering interested clinical and related scholars from around the world to share and collaborate on research around these extremely valuable cases."
Professor Zhao Min, president of the Shanghai Mental Health Center, said that Finis Gage, one of the most famous patients in the history of neuroscience, was damaged by an iron rod through the skull and destroyed the frontal lobe.
Unfortunately, due to the conditions at that time, insufficient records and samples were left. Today, with the advancement of technology, we hope to make up for this shortcoming.
"Compared with building a large cohort database of diseases, special case research is a long-term undertaking, and we will continue to devote ourselves to it day by day," Chen said.World first! Chinese scientists have made a major breakthrough: gene edited pig liver transplantation has been successful, and the patient has been able to move freely on the ground
In the past two years, the xenotransplantation technology of multi-gene edited pigs has made great progress in the United States, and there have been 2 cases of pig to human living transplantation of hearts and 2 cases of kidneys,
and it is happy that there is still 1 kidney transplant patient alive, which brings hope for the eventual development of pig-to-human xenotransplantation. However, American scholars believe that the liver function is too powerful, including metabolism, immunity, hematopoietic, blood clotting and other functions, pig to human xenotransplantation has not been involved.
According to the official wechat account of the First Affiliated Hospital of Anhui Medical University on May 24, the First Affiliated Hospital of Anhui Medical University announced that on May 17, 2024,
Professor Sun Beicheng's team of the First Affiliated Hospital of Anhui Medical University and Professor Wei Hongjiang's team of Yunnan Agricultural University cooperated.
In the First Affiliated Hospital of Anhui Medical University, the genetically modified pig liver was successfully transplanted into a 71-year-old male patient with huge liver cancer in the right lobe. The patient is in good condition.
Today is the seventh day after the operation. About 200ml of golden yellow bile was secreted in the transplanted pig liver every day. CT and B-ultrasound confirmed that the blood flow of hepatic artery, portal vein and hepatic vein of the transplanted pig liver was completely normal.
In this case, xenotransplantation from transgenic pig to living human was successful, which created the first xenotransplantation of transgenic pig liver. After searching, it is the world's first living human xenograft liver transplant operation and the world's fifth living human xenograft organ transplant operation,
which is the original innovation of Chinese scientists from 0 to 1, indicating that Chinese scientists' xenograft liver transplant technology has stood on the forefront of the world and will become one of the most important breakthroughs in the medical field.
In this 10 gene-edited pig to patient liver xenotransplantation, the selected patient is a patient with huge liver cancer in the right lobe. In the case that intervention and other treatments are ineffective and may rupture at any time,
the informed consent of family members and patients is fully obtained based on the principle of compassion and non-harm emergency. The First Affiliated Hospital of Anhui Medical University convened the academic Committee,
the Clinical new technology Ethics Committee, the organ transplantation Ethics Committee and the animal Ethics Committee respectively, and agreed to carry out the xenogeneic assisted liver transplantation research in this patient.
The large tumor of the patient's right liver was first resected. During the operation, it was proved that the remaining left lobe of liver was insufficient to meet the liver function of the patient with liver cancer.Therefore, a 514 gram 10-gene-edited pig (male, aged 11 months, weighing 32kg) liver obtained from the Key Laboratory of Yunnan Small Pig Gene Editing and XenoTransplantation of Yunnan Agricultural University was transplanted into the right liver pit of the patient. The operation went smoothly. The bile was released immediately.
The success of this operation has created a number of miracles in the history of medicine, including the development of global standards on how to implant pig whole liver, the use of immunosuppressants,
and perioperative management of xenograft liver transplantation, making it possible for xenograft pig liver transplantation to enter the clinic, which will make important contributions to human health.
The "liver source" of this xenogeneic liver transplantation comes from Professor Wei Hongjiang's team at Yunnan Provincial Miniature Pig Gene Editing and Xenogeneic Organ Key Laboratory of Yunnan Agricultural University,
who recently developed the latest 10 gene-edited pigs. The edited genes were GTKO, CMAHKO, β4GalNT2KO, hCD46, hCD55, hTBM, hEPCR, hCD47, hCD39, hCD59, which could effectively avoid the hyperacute and acute rejection reaction and coagulation dysfunction of xenotransplantation.
